Triazole
Triazole
Triazole (pronunciation: /traɪˈæzoʊl/) is a class of organic compounds that contain three nitrogen atoms in a five-membered aromatic ring. The term is derived from the Greek words "tri" meaning three, and "azole" which is a class of compounds containing a five-membered ring of atoms.
Structure
There are two isomeric forms of triazole, known as 1,2,3-triazole and 1,2,4-triazole. The difference between these two forms lies in the positions of the nitrogen atoms in the ring. In 1,2,3-triazole, the nitrogen atoms are adjacent to each other, while in 1,2,4-triazole, one nitrogen atom is separated from the other two by a carbon atom.
Synthesis
Triazoles can be synthesized through various methods, including the Huisgen cycloaddition, a type of chemical reaction that forms a five-membered ring from a compound containing a triple bond and a compound containing a double bond.
Applications
Triazoles are used in a wide range of applications, including as building blocks in organic synthesis, as ligands in coordination chemistry, and as antifungal agents in medicine. Some well-known triazole-based drugs include fluconazole, itraconazole, and voriconazole, which are used to treat fungal infections.
Related Terms
- Azole: A class of compounds containing a five-membered ring of atoms.
- Huisgen cycloaddition: A type of chemical reaction used in the synthesis of triazoles.
- Fluconazole: A triazole antifungal medication used to treat and prevent fungal infections.
- Itraconazole: A triazole antifungal medication used to treat a variety of fungal infections.
- Voriconazole: A triazole antifungal medication used to treat serious, potentially life-threatening fungal infections.
External links
- Medical encyclopedia article on Triazole
- Wikipedia's article - Triazole
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