Synaptotropic hypothesis
Synaptotropic Hypothesis
The Synaptotropic Hypothesis (pronunciation: sih-nap-toe-troh-pic hy-po-the-sis) is a theoretical framework in the field of neuroscience that proposes a mechanism for the development and organization of neuronal connections in the brain.
Etymology
The term "Synaptotropic Hypothesis" is derived from the Greek words "synapto" meaning "to join together" and "tropic" meaning "turning towards". The hypothesis thus refers to the idea that synapses, or connections between neurons, are formed and organized in a manner that is directed or influenced by certain factors or conditions.
Overview
The Synaptotropic Hypothesis was first proposed by Vaughn and colleagues in 1988. According to this hypothesis, the growth and development of synapses are influenced by the presence of neurotrophic factors, which are proteins that promote the survival and growth of neurons. The hypothesis suggests that these factors guide the formation and organization of synapses in the brain, leading to the establishment of functional neural circuits.
Related Terms
- Neurotrophic factors: Proteins that promote the survival and growth of neurons. They are thought to play a key role in the Synaptotropic Hypothesis by guiding the formation and organization of synapses.
- Neuron: A nerve cell that is the basic building block of the nervous system. Neurons are interconnected by synapses, the formation and organization of which are proposed to be guided by neurotrophic factors according to the Synaptotropic Hypothesis.
- Synapse: The junction between two neurons where information is transmitted from one neuron to the other. The Synaptotropic Hypothesis proposes a mechanism for the formation and organization of these connections.
- Brain: The organ of the body where neurons and synapses are found. The Synaptotropic Hypothesis is a theory about the development and organization of neuronal connections in the brain.
External links
- Medical encyclopedia article on Synaptotropic hypothesis
- Wikipedia's article - Synaptotropic hypothesis
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