Mallory body
Mallory Body
Mallory Body (pronunciation: /ˈmæləri ˈbɒdi/), also known as Mallory-Denk bodies or Mallory's hyaline, is a type of intracellular inclusion found in the liver cells.
Etymology
The term "Mallory Body" is named after Frank Burr Mallory, an American pathologist who first described these inclusions in 1911.
Definition
Mallory bodies are abnormal aggregates of proteins found in the cytoplasm of liver cells, particularly in conditions such as alcoholic hepatitis, non-alcoholic fatty liver disease, and hepatocellular carcinoma. They are eosinophilic (acidophilic), meaning they stain red or pink with eosin, a red dye used in histology.
Related Terms
- Hepatocyte: The primary type of cell found in the liver. Mallory bodies are often found within these cells.
- Cirrhosis: A late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. Mallory bodies are often found in this condition.
- Ubiquitin: A small protein that is found in almost all cellular tissues. It helps to regulate the processes of other proteins in the body. Mallory bodies are often ubiquitin-positive.
See Also
External links
- Medical encyclopedia article on Mallory body
- Wikipedia's article - Mallory body
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