HaCaT
HaCaT
HaCaT (pronounced: hah-kat) is a spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin. This cell line is widely used in scientific research for the study of keratinocyte behavior and skin-related diseases.
Etymology
The term "HaCaT" is an acronym derived from the German words "Haut" (skin) and "Karzinom" (carcinoma), with the "T" standing for "transformed".
Description
HaCaT cells are a popular model for the study of the molecular mechanisms underlying skin diseases and for the testing of dermatological products. They are characterized by their ability to differentiate in a similar way to normal epidermal keratinocytes, despite their transformed nature.
HaCaT cells are also used in toxicology studies to assess the potential skin irritation and corrosion caused by various substances. They are particularly useful in this context because they can be cultured in vitro, allowing for controlled and reproducible experiments.
Related Terms
- Keratinocyte: A type of cell that makes up the majority of the cells in the epidermis, the outermost layer of the skin.
- Epidermis: The outermost of the three layers that make up the skin, the inner layers being the dermis and hypodermis.
- Dermatology: The branch of medicine dealing with the skin, nails, hair and its diseases.
- Toxicology: The study of the adverse effects of chemical substances on living organisms.
External links
- Medical encyclopedia article on HaCaT
- Wikipedia's article - HaCaT
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