GABA A receptor

GABA A receptor (GABA_A receptor, pronounced as /ˈɡæbə eɪ rɪˈsɛptər/) is a type of GABA receptor that is activated by the neurotransmitter Gamma-Aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system.

Etymology

The term "GABA A receptor" is derived from the neurotransmitter that binds to it, Gamma-Aminobutyric acid (GABA), and the 'A' denotes that it is subtype A of the GABA receptors.

Structure

The GABA A receptor is a multisubunit chloride channel that is activated by GABA. It is a member of the Cys-loop receptors family of ligand-gated ion channels, which also includes the nicotinic acetylcholine receptor, the 5-HT3 receptor, and the glycine receptor.

Function

The GABA A receptor is an inhibitory channel which, when activated, decreases neuronal excitability. This function is essential for the overall balance in neuronal excitability.

Related Terms

• GABA
• GABA receptor
• Gamma-Aminobutyric acid
• Cys-loop receptors
• Neurotransmitter
• Ion channel

See Also

• GABA B receptor
• GABA C receptor

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