Diethylstilbestrol dipropionate
Diethylstilbestrol dipropionate (pronunciation: dye-ETH-il-stil-BES-trol dye-PROE-pee-oh-nate) is a synthetic, nonsteroidal estrogen that was formerly used in the treatment of various medical conditions. It is a derivative of diethylstilbestrol (DES), a drug that was widely prescribed in the mid-20th century to prevent miscarriages and other pregnancy complications.
Etymology
The term "diethylstilbestrol" is derived from the chemical structure of the compound, which consists of two (di-) ethyl groups attached to a stilbene molecule. The suffix "-propionate" refers to the presence of a propionate ester group.
Pharmacology
Diethylstilbestrol dipropionate acts as an agonist of the estrogen receptor, mimicking the effects of natural estrogens in the body. It is more potent than its parent compound, diethylstilbestrol, due to the presence of the propionate ester groups, which enhance its lipid solubility and prolong its duration of action.
Medical uses
Diethylstilbestrol dipropionate was used in the past for a variety of indications, including the treatment of menopausal symptoms, certain types of breast cancer, and prostate cancer. However, its use has been largely discontinued due to the discovery of serious side effects and the development of safer alternatives.
Side effects
The side effects of diethylstilbestrol dipropionate are similar to those of other synthetic estrogens and include nausea, vomiting, fluid retention, and an increased risk of blood clots. Long-term use has been associated with an increased risk of endometrial cancer and other serious health problems.
See also
External links
- Medical encyclopedia article on Diethylstilbestrol dipropionate
- Wikipedia's article - Diethylstilbestrol dipropionate
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