Delta-beta thalassemia
Delta-beta Thalassemia (pronounced: DEL-tuh BAY-tuh thal-uh-SEE-mee-uh) is a form of thalassemia, a group of inherited blood disorders characterized by decreased or absent production of normal hemoglobin, the protein in red blood cells that carries oxygen to cells throughout the body.
Etymology
The term "Delta-beta Thalassemia" is derived from the Greek words "thalassa" meaning "sea" and "haima" meaning "blood", referring to the Mediterranean Sea where the condition was first described. The "Delta-beta" part of the name refers to the specific types of globin chains affected in this condition.
Overview
In Delta-beta Thalassemia, both delta and beta globin chains are affected. This results in a reduced production of hemoglobin A2 and hemoglobin A, the two main types of hemoglobin in adults. The severity of the condition can vary widely, from a mild form with no symptoms to a severe form with life-threatening complications.
Symptoms
Symptoms of Delta-beta Thalassemia can include anemia, fatigue, weakness, pale or yellowish skin, facial bone deformities, slow growth, abdominal swelling, and dark urine.
Diagnosis
Diagnosis of Delta-beta Thalassemia is typically made through a complete blood count (CBC) and a hemoglobin electrophoresis test. Genetic testing may also be used to confirm the diagnosis and identify the specific mutations causing the condition.
Treatment
Treatment for Delta-beta Thalassemia can include blood transfusions, iron chelation therapy to remove excess iron from the body, and in severe cases, a bone marrow transplant.
Related Terms
External links
- Medical encyclopedia article on Delta-beta thalassemia
- Wikipedia's article - Delta-beta thalassemia
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