Colony stimulating factor 1 receptor

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Colony Stimulating Factor 1 Receptor (CSF1R)

Colony Stimulating Factor 1 Receptor (pronounced as: kɒləni stɪmjʊleɪtɪŋ fæktər wʌn rɪsɛptər), also known as CSF1R, is a type of protein that in humans is encoded by the CSF1R gene.

Etymology

The term "Colony Stimulating Factor 1 Receptor" is derived from its function. "Colony Stimulating Factor" refers to the protein's role in stimulating the growth and differentiation of hematopoietic precursors into mature leukocytes. The "1 Receptor" indicates that it is the first identified receptor for this factor.

Function

CSF1R is a tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and interleukin 34 (IL34). It plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.

Related Terms

  • Protein: Large, complex molecules that play many critical roles in the body. They do most of the work in cells and are required for the structure, function, and regulation of the body's tissues and organs.
  • Gene: The basic physical and functional unit of heredity. Genes are made up of DNA.
  • Leukocytes: Also known as white blood cells, they are a part of the immune system and help our bodies fight off infections.
  • Tyrosine-protein kinase: An enzyme that can transfer a phosphate group from ATP to a protein in a cell.
  • CSF1: A cytokine that controls the production, differentiation, and function of macrophages.
  • Interleukin 34 (IL34): A protein that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R).
  • Macrophages: A type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, and cancer cells.
  • Monocytes: A type of leukocyte, or white blood cell.

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