Activated protein C resistance
Activated Protein C Resistance
Activated protein C resistance (APCR) is a hematological disorder that results in an increased risk of blood clot formation (thrombosis). The condition is often associated with Factor V Leiden, a mutation of one of the clotting factors in the blood called factor V.
Pronunciation
Activated protein C resistance: /ækˈtɪveɪtɪd ˈproʊtiːn siː rɪˈzɪstəns/
Etymology
The term "Activated protein C resistance" is derived from the nature of the condition. "Activated" refers to the state of protein C, a protein in the blood that prevents clotting. "Resistance" refers to the reduced ability of protein C to perform its function due to a mutation in factor V.
Related Terms
- Thrombophilia: A group of disorders characterized by a predisposition towards forming blood clots.
- Factor V Leiden: A mutation of factor V, one of the clotting factors in the blood.
- Protein C: A protein in the blood that prevents clotting.
- Prothrombin G20210A: A genetic condition that increases the risk of blood clots.
- Venous thromboembolism: A condition in which a blood clot forms in the veins.
Symptoms
Activated protein C resistance does not cause symptoms unless a blood clot forms. Symptoms of a blood clot depend on where it forms in the body, but can include pain, swelling, redness, and warmth over the area of the clot.
Diagnosis
Diagnosis of activated protein C resistance is typically made through blood tests that measure the ability of protein C to prevent clotting. Genetic testing may also be performed to identify the presence of the factor V Leiden mutation.
Treatment
Treatment for activated protein C resistance typically involves medications to reduce the risk of blood clot formation. These may include anticoagulant medications, such as warfarin or heparin.
See Also
External links
- Medical encyclopedia article on Activated protein C resistance
- Wikipedia's article - Activated protein C resistance
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