Microsatellite Instability

Microsatellite Instability
Term	Microsatellite Instability
Short definition	Microsatellite Instability - (pronounced) (MY-kroh-SA-teh-lite in-stuh-BIH-lih-tee) change that occurs in certain cells (such as cancer cells) in which the number of repeating DNA bases in a microsatellite (a short, repeating sequence of DNA) is different than the inheritance of the microsatellite. Microsatellite instability can be caused by errors that are not corrected when DNA is copied into a cell.
Type	Cancer terms
Specialty	Oncology
Language	English
Source	NCI
Comments

Microsatellite Instability - (pronounced) (MY-kroh-SA-teh-lite in-stuh-BIH-lih-tee) change that occurs in certain cells (such as cancer cells) in which the number of repeating DNA bases in a microsatellite (a short, repeating sequence of DNA) is different than the inheritance of the microsatellite. Microsatellite instability can be caused by errors that are not corrected when DNA is copied into a cell. It is most commonly found in colon cancer, stomach cancer, and endometrial cancer, but can also be found in many other cancers. Knowing if a cancer has microsatellite instability can help plan the best treatment. Also called MSI

External links

• Medical encyclopedia article on Microsatellite Instability
• Wikipedia's article - Microsatellite Instability

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