View source for Nacolomab tafenatox

'''Nacolomab tafenatox''' (pronunciation: na-co-lo-mab ta-fe-na-tox) is a [[therapeutic antibody]] used in the treatment of certain types of [[cancer]]. It is a [[monoclonal antibody]] that has been conjugated with a [[toxin]], specifically the [[Pseudomonas]] exotoxin. 

==Etymology==
The name "Nacolomab tafenatox" is derived from the following components: "Naco" refers to the target antigen (N-acetylglucosaminyltransferase V), "lo" indicates that it is a low-affinity antibody, "mab" is an abbreviation for monoclonal antibody, and "tafenatox" is a reference to the Pseudomonas exotoxin.

==Mechanism of Action==
Nacolomab tafenatox works by binding to the N-acetylglucosaminyltransferase V antigen on the surface of cancer cells. Once bound, the toxin component of the drug is internalized by the cell, where it inhibits protein synthesis and ultimately leads to cell death.

==Related Terms==
* [[Monoclonal antibody]]
* [[Therapeutic antibody]]
* [[Pseudomonas exotoxin]]
* [[N-acetylglucosaminyltransferase V]]
* [[Protein synthesis]]
* [[Cell death]]

==See Also==
* [[List of monoclonal antibodies]]
* [[List of cancer treatments]]

[[Category:Monoclonal antibodies]]
[[Category:Cancer treatments]]
[[Category:Therapeutic antibodies]]

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