View source for Loss of heterozygosity

'''Loss of heterozygosity''' ('''LOH''') is a [[genetic]] event that results in the loss of normal function of one [[allele]] of a gene where the other allele was already inactivated. 

==Pronunciation==
* Loss of heterozygosity: /ˈlɒs ɒv ˌhɛtərəˈzɒɡəsi/

==Etymology==
The term "Loss of heterozygosity" is derived from the field of [[genetics]]. "Loss" refers to the disappearance or reduction of something. "Heterozygosity" is a term used in genetics to describe a state where an individual has different alleles at a gene locus.

==Definition==
In the context of [[genetics]], Loss of heterozygosity (LOH) refers to the event that leads to the loss of the normal function of one allele of a gene when the other allele was already inactivated. This event is significant in the development of many types of [[cancer]].

==Related Terms==
* [[Allele]]
* [[Gene]]
* [[Genetics]]
* [[Cancer]]
* [[Mutation]]
* [[Genomic instability]]

==See Also==
* [[Knudson hypothesis]]
* [[Tumor suppressor gene]]
* [[Oncogene]]

==References==
* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075942/ Loss of heterozygosity in tumor growth]

[[Category:Genetics]]
[[Category:Medical terminology]]
[[Category:Cancer]]
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