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'''Estrone (medication)'''

'''Estrone''' (pronunciation: /ˈɛstrəʊn/), also known as '''E1''' and '''oestrone''', is a naturally occurring [[estrogen]] steroid hormone and a minor female sex hormone. It is one of three major endogenous estrogens, the others being [[estradiol]] and [[estriol]].

==Etymology==
The term "estrone" is derived from the Greek ''oistros'', meaning "gadfly" or "frenzy", and ''one'', a suffix used in chemical nomenclature to denote a ketone.

==Pharmacology==
Estrone is synthesized from [[androstenedione]], a steroid hormone produced in the adrenal glands and gonads. It is converted into estrone by the enzyme [[aromatase]]. Estrone can also be converted back into androstenedione.

==Medical Uses==
Estrone is used in hormone replacement therapy to treat symptoms of menopause in women. It is also used in the treatment of breast cancer and prostate cancer. 

==Side Effects==
Common side effects of estrone include nausea, vomiting, breast tenderness, irregular menstrual periods, and weight changes. More serious side effects may include blood clots, stroke, and heart disease.

==Related Terms==
* [[Estrogen]]: A group of steroid hormones that promote the development and maintenance of female characteristics of the body.
* [[Estradiol]]: The most potent and prevalent endogenous estrogen sex hormone.
* [[Estriol]]: A minor endogenous estrogen sex hormone.
* [[Androstenedione]]: A steroid hormone that is a common precursor in the biochemical synthesis of estrone.
* [[Aromatase]]: An enzyme that synthesizes estrogen.

==See Also==
* [[Hormone replacement therapy]]
* [[Menopause]]
* [[Breast cancer]]
* [[Prostate cancer]]

[[Category:Medications]]
[[Category:Hormones]]
[[Category:Estrogens]]

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