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== DDX11 ==

'''DDX11''' (pronounced: D-D-X-eleven), also known as '''ChlR1''' or '''Chl1''', is a gene that encodes a DNA helicase in humans. This gene is associated with [[Warsaw breakage syndrome]], a rare congenital disorder.

=== Etymology ===

The term DDX11 is an abbreviation for "DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11". The DEAD/H box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp/His (DEAD/H), are putative [[RNA helicases]]. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as [[translation initiation]], nuclear and mitochondrial [[splicing]], and [[ribosome]] and [[spliceosome]] assembly.

=== Function ===

The DDX11 gene is a member of the [[DEAD box protein]] family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The DDX11 protein is a DNA helicase that is important for [[DNA replication]] and [[sister chromatid cohesion]].

=== Related Terms ===

* [[DEAD box protein]]: A family of proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). They are putative RNA helicases.
* [[Warsaw breakage syndrome]]: A rare congenital disorder associated with the DDX11 gene.
* [[DNA replication]]: The process of producing two identical replicas from one original DNA molecule.
* [[Sister chromatid cohesion]]: The process by which sister chromatids are paired and held together from the time of their formation in S phase until their separation in anaphase.

=== See Also ===

* [[DNA helicase]]
* [[RNA helicase]]
* [[Translation initiation]]
* [[Splicing]]
* [[Ribosome]]
* [[Spliceosome]]

[[Category:Genes]]
[[Category:DNA]]
[[Category:RNA]]
[[Category:Proteins]]
[[Category:Medical Dictionary]]

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