View source for BMS-345541

== BMS-345541 ==

'''BMS-345541''' (pronunciation: B-M-S-Three-Four-Five-Five-Four-One) is a highly selective inhibitor of [[IKK]] (IκB kinase). It is often used in scientific research to study the role of [[NF-κB]] in various biological processes.

=== Etymology ===

The term "BMS-345541" is a compound name derived from the initials of the pharmaceutical company Bristol-Myers Squibb (BMS) and the unique identifier number 345541 assigned to this specific inhibitor during its development.

=== Usage ===

BMS-345541 is used in scientific research to inhibit the activity of IKK, a kinase that plays a crucial role in the activation of NF-κB. By inhibiting IKK, BMS-345541 can prevent the activation of NF-κB, allowing researchers to study the effects of NF-κB inhibition on various biological processes.

=== Related Terms ===

* [[IKK]]: IκB kinase, the enzyme that BMS-345541 inhibits.
* [[NF-κB]]: Nuclear factor kappa-light-chain-enhancer of activated B cells, a protein complex that controls transcription of DNA, cytokine production and cell survival.
* [[Inhibitor]]: A substance that slows down or prevents a particular chemical reaction or other process, or that reduces the activity of a particular reactant, catalyst, or enzyme.
* [[Kinase]]: An enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

[[Category:Pharmacology]]
[[Category:Biochemistry]]
[[Category:Medical Dictionary]]

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