View source for AMG 162

{{Definitions
|Term=AMG 162
|Short definition=AMG 162 - A drug used to prevent or treat certain bone problems. AMG 162 is used under the brand name Xgeva to prevent bone problems caused by multiple myeloma or by solid tumors that have spread to the bone. 
|Type=Cancer terms
|Specialty=Oncology
|Language=English
|Source=NCI
}}
AMG 162 - A drug used to prevent or treat certain bone problems. AMG 162 is used under the brand name Xgeva to prevent bone problems caused by multiple myeloma or by solid tumors that have spread to the bone. It is also used in certain patients to treat giant cell tumors of the bone that cannot be surgically removed and to treat hypercalcaemia related to cancer that has not improved after treatment with bisphosphonates. AMG 162 is also used under the brand name Prolia to increase bone mass in certain patients with breast cancer or prostate cancer who are at high risk of fractures. It is also used to treat osteoporosis in certain patients who are at high risk of breaking bones. AMG 162 is also being studied to treat other conditions and cancers. It attaches to a protein called RANKL, which prevents RANKL from attaching to another protein called RANK on the surface of certain bone cells, including bone cancer cells. This can help prevent bone loss and cancer cell growth. AMG 162 can also prevent the loss of calcium from the bones. It's a type of monoclonal antibody. Also called denosumab {{dictionary-stub}} [[Category:Dictionary of medicine]]