View source for ALOX12B

== ALOX12B ==

'''ALOX12B''' (pronounced as A-L-O-X-12-B), also known as '''Arachidonate 12-Lipoxygenase, 12R Type''', is a gene that encodes a member of the lipoxygenase family of enzymes. It is involved in the metabolism of arachidonic acid and plays a significant role in the skin barrier function.

=== Etymology ===

The term '''ALOX12B''' is an abbreviation derived from '''Arachidonate 12-Lipoxygenase, 12R Type'''. The term 'Arachidonate' refers to arachidonic acid, a polyunsaturated omega-6 fatty acid, while 'Lipoxygenase' is an enzyme that oxygenates lipids. The '12R' denotes the specific type of lipoxygenase that this gene encodes.

=== Function ===

The [[ALOX12B]] gene is part of the lipoxygenase pathway, which is a key component in the biosynthesis of leukotrienes, lipoxins, and other bioactive lipids. The enzyme encoded by this gene converts arachidonic acid exclusively to 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE), and further metabolizes it to hepoxilins. These hepoxilins are involved in the formation of the skin barrier, making the [[ALOX12B]] gene crucial for skin health.

=== Related Terms ===

* [[Arachidonic Acid]]: A polyunsaturated omega-6 fatty acid involved in the metabolism of the ALOX12B gene.
* [[Lipoxygenase]]: An enzyme that oxygenates lipids, encoded by the ALOX12B gene.
* [[Leukotrienes]]: Bioactive lipids synthesized as part of the lipoxygenase pathway.
* [[Lipoxins]]: Another type of bioactive lipids synthesized as part of the lipoxygenase pathway.
* [[Hepoxilins]]: Metabolites of 12R-HPETE, involved in the formation of the skin barrier.

=== See Also ===

* [[ALOXE3]]
* [[Epidermis]]
* [[Ichthyosis]]

[[Category:Genes]]
[[Category:Enzymes]]
[[Category:Biochemistry]]
[[Category:Dermatology]]

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